Clinical Pharmacy Department                         Diploma course specifications (2013-2014) 
                   
                                                        Immunopharmacology 
                  Ain Shams University                                                     
                  Faculty of Pharmacy 
                  Department of Clinical Pharmacy                
                  Course specifications 
                  Programme on which the course is given: Diploma of Pharmacy 
                  Department offering the course: Clinical Pharmacy 
                  Academic year / Level: postgraduate (diploma) 
                  Date of specification revision:                         9/2013 
                  A- Basic Information 
                       Title:               Immunopharmacology                                                     
                        Credit Hours:       2hr/wk             
                       Lecture:   2hr/wk   
                       Practical:              -                     
                       Total taught hrs:             2hr/wk             
                  B- Professional Information 
                      1 – Overall aim of course 
                  Upon completion of this course, the diploma students should  
                      •  have good knowledge of the immune system, the clinical features of some 
                           autoimmune diseases.  
                      •  have detailed explanation of the immunostimulants and the immunosuppressants. 
                           Hypersensitivity reactions and transplantation are also highlighted 
                  2 – Intended learning outcomes of course (ILOs) 
                  a.  Knowledge and understanding: 
                  The student should be able to: 
                  a1- Explain the clinical presentations of some autoimmune diseases  
                  a2- Explain the clinical management of systemic lupus erythematosus and 
                  thrombocytopenia.    
                  a3- Demonstrate and illustrate different mechanisms of immune deficiency 
                Clinical Pharmacy Department                         Diploma course specifications (2013-2014) 
                
               a4- Define and explain the immune system 
               a5- Predict  the relationship between drugs and the immune system  
               b.  Intellectual skills 
               The student should be able to work autonomously or with minimal guidance to: 
               b1- Analyze and interpret some autoimmune clinical disorders  
               b2- Handle different types of immune difficiency using different therapeutic approaches 
               The student should be able to 
               b3-Distinguish between different types of hypersensitivity reactions 
               c.  Professional and practical skills 
               The student should be able to: 
               c1- Define and explain signs and symptoms of some autoimmune diseases, advice patients 
               and physician of the proper regimens in them.  
               d.  General and transferable skills 
               The student should be able to 
               d1- Write reports  
               d2- Learn basic information and know how to upload them 
               d3- Use web browsing to locate and use online data bases. 
               3- Contents 
               Topic                                            No. of hours      Lecture      Tutorial/ 
                                                                                               Practical 
                     Dr. Khaled Abo Shanab                                                      
                 –  Introduction to immune system               2                 1            - 
                 –  Imuunity (types, innate and acquired)       2                 1            - 
                 –  Active and passive immunity                 2                 1            - 
                 –  Cytokines (macrokines and lymphokines)      2                 1            - 
                 –  Antigens 
                 –  Immunoglobulins                                                             
                 –  Immunological agents (vaccines and          2                 1            - 
                     antiserums)                                2                 1            - 
                 –  Overview about immune system abberation     2                 1            - 
                 –  MHC receptor (type I,II,III) 
                     Clinical Pharmacy Department                         Diploma course specifications (2013-2014) 
                    
                     –    Monoclonal antibodies and their role in                                                           - 
                           therapeutic and diagnostic purposes                     2                      1                  
                                                                                                                            - 
                                                                                   2                      1                  
                                                                                   2                      1                 - 
                                                                                                                            - 
                                                                                                                             
                                                                                                                             
                     Dr. Samar El Azab                                                                                       
                        –    Immunosuppressants (introduction and                  10                     5                 - 
                             classes)                                                                                        
                        –    Immunostimulants                                      6                      3                 - 
                        –    Cancer stem cell therapy                              8                      4                 - 
                     Dr. Gouda Kamel                                                                                         
                                                                                   10                     5                 - 
                        -    Graves' Disease:                                                                                
                                 o  Definition, causes and etiology.                                                         
                                 o  Signs, symptoms and diagnosis.                                                           
                                 o  Treatment                                                                                
                                                                                                                             
                        -    Rheumatoid Arthritis:                                                                           
                                 o  Definition, signs and symptoms                                                           
                                                                                   8                      4                 - 
                                                                                                                             
                                 o  Diagnosis (history, RF, CCP,                                                             
                                      ESR, CRP, CBC, X-ray and                                                               
                                      MRI).                                                                                  
                                 o  Treatment:                                                                               
                                                                                                                             
                        -    Adrenal Insufficiency & Addison's                                                               
                        Disease:                                                                                             
                                 o  Introduction to adrenal gland,                                                           
                                      definition of adrenal                        6                      3                  
                                      insufficiency, etiology.                                                               
                                 o  Signs, symptoms and diagnosis(                                                          - 
                                      cortisol, ACTH stimulation test,                                                       
                                      aldosterone, BUN, creatinine,                                                          
                                      Glucose and electrolytes).                                                             
                                 o  Treatment                                                                                
                                 o  Patient education. 
                 Clinical Pharmacy Department                         Diploma course specifications (2013-2014) 
                
                                                                                                   
                   -    Systemic Lupus Erythematosus:                                              
                          o  Definition, etiology, signs and                                       
                              symptoms.                                                            
                          o  Diagnosis (ANA, Anti-Sm                                               
                              antibody, anti-ds DNA, anti-SSA                                      
                              and SSB, RF, CRP, ESR, VDRL,       6                  3              
                              SPEP, urinalysis and CBC).                                           
                          o  Treatment                                                             
                          o  How to educate patient to prevent                                     
                              flares.                                                             - 
                          o  SLE and pregnancy. 
                
                  
                 Dr. Hala Fahmy                                                                    
                                                                                                   
                   -    Cancer immunotherapy                            10          5             - 
                          o  Cancer vaccines: HPV vaccine                                          
                              and therapeutic cancer vaccine.                                      
                          o  Target elements on tissue for                                         
                              immunotherapy:                                                       
                                 ƒ   Tumor antigens.                                               
                                 ƒ   Tumor cell surface                                            
                                     receptor.                                                     
                                 ƒ   Growth factors.                                               
                          o  Monoclonal antibodies for                                             
                              treatment.                                                           
                          o  Antibody-dependent cell-                                              
                              mediated cytotoxicity by NK cells                                    
                                                                                                   
                   -    Immune system Aberration:                                                  
                          o  Hypersensitivity Diseases: Type                                       
                              I, II, III, IV hypersensitivity                                      
                              reaction.                                                            
                          o  Congenital and acquired                    10          5              
                              immunodeficiencies.                                                  
                          o  AIDs and treatment.                                                  - 
                          o  Autoimmunity: causes and                                              
                              treatment.                                                           
                   -    Immunostimulants and                                                       
                   immunosuppressants                                                              
                          o  Indications of Immunotherapy                                          
                          o  Immunosuppressants:                                                   
                              mechanisms of action.                                                
                          o  Classification                             10          5              
                          o  Immunostimulants: