MODULE 8 
                     
                       Module name                 Drug Design and Evaluation 
                       Module level, if            Bachelor 
                       applicable 
                       Code, if applicable         301N1103 
                       Subtitle, if applicable     - 
                       Courses, if applicable      Pharmaceutical Analysis 
                       Semester(s) in which        III 
                       the module is taught 
                       Person responsible for      Prof. Dr. Asnah Marzuki, Apt. 
                       the module 
                                                   Prof. Dr. Asnah Marzuki, Apt. 
                       Lecturer                    Syaharuddin Kasim, M.Si., Apt. 
                                                   Aminullah, M.Pharm,Sc., Apt. 
                       Language                    Bahasa 
                       Relation curriculum         Compulsory in semester III , for Bachelor degree in 
                                                   Pharmacy 
                       Type of teaching,           Lectures (2 hours) 
                       contact hours               Group Discussions (1 hr) 
                                                   Practical Sessions (3 hours) 
                                                   Contact hours: 15 weeks x 2 hours 
                       Workload                    Independent study: 15 weeks x 2 hours 
                                                   Practical sessions: 15 weeks x 3 hours 
                       Credit points               3 SKS OR 5.1 CP (ECTS) 
                       Requirements 
                       according to the            Attendance policy: absences greater than 20% of the 
                       examination                 material are not eligible for final 
                       regulations 
                       Recommended                 Completion of modules: 
                       prerequisites               Analytical Chemistry 
                                                   After the completion of this module, participants will gain 
                                                   knowledge, skill and competence as follows: 
                                                   Knowledge: 
                                                   Participants will be able to: 
                                                    •   Understand the procedure of sample preparation and 
                                                        the principle of analtical chemistry method 
                                                    •   Analyze of chemical substance or drug product by 
                                                        qualitative and quantitative, separation of the 
                       Module objectives                components of a solution or mixture. 
                                                    •   Determinate of structure of chemical compounds. 
                                                    •   Develop a new method for analyzes of chemical 
                                                        compound or drug product 
                                                    •   Design such as method validation handling raw 
                                                        materials and finished products, ocumentations, 
                                                        inspections that impact the development of 
                                                        pharmaceutical products 
                                                   
                                                   Skill: 
                                               Participants will be able to understand the procedures, to 
                                               prepare of sample and using instruments for analyses 
                                               qualitative and quantitative of the chemistries using 
                                               several methods. 
                                               
                                               Competence: 
                                               Participants will be able to analyses qualitatively and 
                                               quantitatively of the chemistries using the right procedures 
                                               of the most suitable method. 
                                               This module is designed to develop material of Analytical 
                                               Chemistry. Previously, participants who have joined the 
                                               Analytical Chemistry materials are able to demonstrate 
                                               analysis of chemicals by using instrument with several 
                                               methods. This module is a further development. 
                                               Participants are equipped with material so as to perform 
                                               qualitative and quantitative chemical analysis whose 
                                               results can be accounted scientifically. 
                                               
                                               The laboratory sessions are designed to give further 
                                               understanding of the procedures of the most suitable 
                                               methods for sample preparation and 
                                               qualitative/quantitative analyses of chemistries. 
                                               Additional skill is given in how to understand the structure 
                                               of chemistries and their characteristics. 
                                               
                     Content                   Topics covered may include: 
                                               ▪  Basic methods and application of pharmaceutical 
                                                  analysis 
                                               ▪  Quantitative    analysis   of   monocomponent  and 
                                                  multicomponent by spectrophotometry 
                                               ▪  Quantitative    analysis   of   monocomponent  and 
                                                  multicomponent by spectrofluorometry 
                                               ▪  Analysis of drug by spectrophotometric derivatives 
                                               ▪  Analysis of drug by TLC-Densitometry 
                                               ▪  Analysis of drug by HPLC method 
                                               ▪  Analysis of drug by Gas Chromatography method 
                                               ▪  Analysis    of   analgesic,   antipyretic   and    anti- 
                                                  inflammatory drugs with several instruments 
                                               ▪  Analysis of sulfonamide drug with several instruments 
                                               ▪  Analysis of xanthine and barbiturates with several 
                                                  instruments 
                                               ▪  Analysis of antibiotic drug with several instruments 
                                               Students are marked based on their performance in theory 
                     Study and examination     (70%) and practicum (30%). 
                     requirements and forms  Performance in theory: 
                     of examination             •   Final Exam (50%) 
                                                •   Group discussion and presentation (40%) 
                                                •   Individual quiz(10%) 
                                                Performance in practicum: 
                                                 •   Practical exam (25%) 
                                                 •   Preparation, assignments and quizzes (15%) 
                    
                                                 •   Participation during experiments (30%) 
                                                 •   Discussion and reports (30%) 
                                                Lectures: slides, handouts, animation, white board 
                                                Group discussion: participants are divided in small 
                                                groups to address specific questions within the groups 
                                                before discussing them with the whole class. The process 
                                                is facilitated by lecturer(s). 
                                                Group presentation and posters: participants are divided 
                    Media employed              in small groups and given specific topic to be presented 
                                                using slides or posters in front of the class. The 
                                                presentation is marked by peers and lecturer(s). 
                                                Practicum: Participants are divided into small groups. 
                                                Experiments and assays are demonstrated by participants 
                                                based on practicum manuals and supervised by laboratory 
                                                assistants and lecturer(s). 
                                                David.G. Watson, Pharmaceutical Analysis: a textbook 
                                                for pharmacy students and pharmaceutical chemists, 
                                                Elsevier Publication, 2005. 
                                                
                                                Silverstein, R. M, Spectrometric Identification of Organic 
                                                Compounds, John Wiley and Sons, 2005. 
                                                
                                                       ,
                    Reading list                Ewings, Analytical Instrumentation Handbook, 2005, 
                                                Third Edition. Florida Atlantic University Boca Raton, 
                                                Florida, USA. 
                                                
                                                Sudjadi, Rohman. Analisis Farmasi. Penerbit Pustaka 
                                                Pelajar. 
                                                
                                                Abdul Rohman. Analisis Obat. Gadjah Mada Universit 
                                                Press.